Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: A case-control study

N Johnson; F Dudbridge; N Orr; L Gibson; ME Jones; MJ Schoemaker; EJ Folkerd; BP Haynes; JL Hopper; MC Southey; GS Dite; C Apicella; MK Schmidt; A Broeks; LJ Van't Veer; F Atsma; K Muir; A Lophatananon; PA Fasching; MW Beckmann; AB Ekici; SP Renner; E Sawyer; I Tomlinson; M Kerin; N Miller; B Burwinkel; F Marme; A Schneeweiss; C Sohn; P Guénel; T Truong; E Cordina; F Menegaux; SE Bojesen; BG Nordestgaard; H Flyger; R Milne; MP Zamora; JIA Perez; J Benitez; L Bernstein; H Anton-Culver; A Ziogas; CC Dur; H Brenner; H Müller; V Arndt; AK Dieffenbach; A Meindl; J Heil; CR Bartram; RK Schmutzler; H Brauch; C Justenhoven; YD Ko; H Nevanlinna; TA Muranen; K Aittomäki; C Blomqvist; K Matsuo; T Dörk; NV Bogdanova; NN Antonenkova; A Lindblom; A Mannermaa; V Kataja; VM Kosma; JM Hartikainen; G Chenevix-Trench; J Beesley; AH Wu; D Van den Berg; CC Tseng; D Lambrechts; D Smeets; P Neven; H Wildiers; J Chang-Claude; A Rudolph; S Nickels; D Flesch-Janys; P Radice; P Peterlongo; B Bonanni; V Pensotti; FJ Couch; JE Olson; X Wang; Z Fredericksen; VS Pankratz; GG Giles; G Severi; L Baglietto; C Haiman; J Simard; MS Goldberg; F Labrèche; M Dumont; P Soucy

Journal article

Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: A case-control study

N Johnson, F Dudbridge, N Orr, L Gibson, ME Jones, MJ Schoemaker, EJ Folkerd, BP Haynes, JL Hopper, MC Southey, GS Dite, C Apicella, MK Schmidt, A Broeks, LJ Van't Veer, F Atsma, K Muir, A Lophatananon, PA Fasching, MW Beckmann Show all

Breast Cancer Research | BMC | Published : 2014

DOI: 10.1186/bcr3662

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Abstract

Introduction: We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years. Methods: We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagno..

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